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Question 1
Which autoantibody is the most specific for systemic lupus erythematosus?
- Anti-dsDNA
- Antinuclear antibody (ANA)
- Anti-histone
- Anti-Scl-70
Question 2
Which autoantibody is the most sensitive for systemic lupus erythematosus?
- Antinuclear antibody (ANA)
- Anti-Smith
- Anti-U1 RNP
- Anticentromere
Question 3
Which autoantibody correlates best with kidney disease activity in systemic lupus erythematosus?
- Anti-dsDNA
- Antinuclear antibody (ANA)
- Anti-histone
- Anti-SSA (anti-Ro)
Question 4
Anti-glomerular basement membrane antibodies are associated with which condition?
- Goodpasture syndrome
- Primary membranous nephropathy
- Granulomatosis with polyangiitis
- IgA nephropathy
Question 5
Anti-TSH receptor antibodies are associated with which disease?
- Graves disease
- Hashimoto thyroiditis
- Pernicious anemia
- Type 1 diabetes mellitus
Question 6
Antimitochondrial antibodies are associated with primary sclerosing cholangitis.
- True
- False
Question 7
Anti-desmoglein (anti-desmosome) antibodies are associated with which blistering disease?
- Pemphigus vulgaris
- Bullous pemphigoid
- Dermatomyositis
- Celiac disease
Question 8
Anticentromere antibodies are most characteristic of which condition?
- Limited cutaneous scleroderma (CREST syndrome)
- Diffuse scleroderma
- Mixed connective tissue disease
- Drug-induced lupus
Question 9
Anti-U1 ribonucleoprotein (anti-U1 RNP) antibodies are associated with which condition?
- Mixed connective tissue disease
- Systemic lupus erythematosus
- Sjögren syndrome
- Autoimmune hepatitis type I
Question 10
IgA antibodies against which enzyme, together with IgA anti-endomysial antibodies, are associated with celiac disease?
Fill in the blank
Question 11
Anti-histone antibodies are associated with which condition?
- Drug-induced lupus
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Antiphospholipid syndrome
Question 12
Rheumatoid factor is an IgM antibody directed against the Fc region of IgG, while anti-CCP is more specific for rheumatoid arthritis.
- True
- False
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