Quiz 🩺 Medicine
First Aid for the USMLE Step 1 Quiz
Quiz generated from First Aid for the USMLE Step 1
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Question 1
Which blotting technique is used to detect RNA?
- Northern blot
- Southern blot
- Western blot
- Eastern blot
Question 2
Which type of molecule is used as a probe in a Western blot?
- Antibodies
- DNA
- RNA
- Lipids
Question 3
What is the correct order of the main steps in PCR?
- Denature DNA, anneal primers, elongate with heat-stable DNA polymerase
- Anneal primers, denature DNA, elongate with heat-stable DNA polymerase
- Elongate with heat-stable DNA polymerase, denature DNA, anneal primers
- Denature DNA, elongate with heat-stable DNA polymerase, anneal primers
Question 4
Which cells are permanent cells that remain in G0?
- Neurons, cardiac muscle cells, and red blood cells
- Hepatocytes and lymphocytes
- Bone marrow, gut, and skin cells
- Goblet cells and plasma cells
Question 5
Which organelle is the primary site of steroid synthesis and detoxification of drugs and poisons?
- Smooth endoplasmic reticulum
- Rough endoplasmic reticulum
- Golgi apparatus
- Lysosome
Question 6
N-linked oligosaccharide addition occurs in which organelle?
Fill in the blank
Question 7
The Golgi apparatus adds mannose-6-phosphate to proteins to target them to lysosomes.
- True
- False
Question 8
What is the molecular defect in I-cell disease?
- Failure to add mannose-6-phosphate in the Golgi
- Defective microtubule polymerization
- Failure of clathrin-mediated endocytosis
- Inability to synthesize lysosomal enzymes
Question 9
COPII-coated vesicles mediate which transport step?
- Anterograde transport from the rough endoplasmic reticulum to the cis-Golgi
- Retrograde transport from the Golgi to the ER
- Transport from the trans-Golgi to lysosomes
- Transport from the plasma membrane to endosomes
Question 10
Chediak-Higashi syndrome results from a microtubule polymerization defect that decreases phagosome-lysosome fusion.
- True
- False
Question 11
Which organelle assembles proteoglycans from core proteins and sulfates sugars in proteoglycans?
- Golgi apparatus
- Rough endoplasmic reticulum
- Smooth endoplasmic reticulum
- Lysosome
Question 12
Which anti-breast cancer drug acts on microtubules?
- Taxol
- Tamoxifen
- Methotrexate
- Trastuzumab
Question 13
Which antifungal drug acts on microtubules?
- Griseofulvin
- Colchicine
- Vincristine
- Mebendazole
Question 14
Which of the following is an anticancer agent that acts on microtubules?
- Vincristine
- Griseofulvin
- Thiabendazole
- Colchicine
Question 15
Kinesin mediates anterograde transport, moving cargo from the minus end toward the plus end of the microtubule.
- True
- False
Question 16
Which drug used to treat gout acts on microtubules?
- Colchicine
- Griseofulvin
- Vincristine
- Mebendazole
Question 17
Dynein carries out which direction of transport along a microtubule?
- Retrograde, from the plus end toward the minus end
- Anterograde, from the minus end toward the plus end
- Only along the central pair of microtubules
- It does not move along microtubules
Question 18
Dynein moves cargo from the plus end toward the minus end of a microtubule.
- True
- False
Question 19
A dynein arm defect causing male and female infertility, bronchiectasis, and recurrent sinusitis is characteristic of which syndrome?
- Kartagener syndrome
- Marfan syndrome
- Alport syndrome
- Ehlers-Danlos syndrome
Question 20
Each alpha- and beta-tubulin dimer in a microtubule binds how many GTP molecules?
Fill in the blank
Question 21
Which statement best describes microtubule growth dynamics?
- They grow slowly and collapse quickly
- They grow quickly and collapse slowly
- They grow and collapse at the same rate
- They neither grow nor collapse once formed
Question 22
Which drug is an antihelminthic that acts on microtubules?
- Mebendazole
- Griseofulvin
- Colchicine
- Vincristine
Question 23
Collagen is the most abundant protein in humans.
- True
- False
Question 24
Collagen contains a repeating amino acid motif; identify it (written as three single-letter amino acid symbols separated by hyphens).
Fill in the blank
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