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Anatomic Pathology Board Study (AP-Part1) Quiz

Quiz generated from Anatomic Pathology Board Study (AP-Part1)

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Question 1

Which laboratory finding is characteristic of Wilson disease?

Decreased serum ceruloplasmin
Increased serum ceruloplasmin
Decreased serum alpha-1 antitrypsin
Increased serum transferrin saturation

Question 2

What is the most common glomerulonephritis?

IgA nephropathy
Membranous nephropathy
Pauci-immune crescentic glomerulonephritis
Post-infectious glomerulonephritis

Question 3

Which syndrome is strongly associated with renal cell carcinoma?

Von Hippel-Lindau syndrome
Tuberous sclerosis
Gardner syndrome
Alport syndrome

Question 4

In extramammary Paget disease, which marker may be positive and help guide therapy?

HER2/neu
Estrogen receptor
Progesterone receptor
CD30

Question 5

Paget disease of the vulva usually indicates an underlying breast or vulvar cancer more serious than ductal carcinoma in situ (DCIS).

True
False

Question 6

Which long-term malignancies are associated with celiac disease?

Enteropathy-associated T-cell lymphoma and adenocarcinoma
Gastric carcinoid and hepatocellular carcinoma
Renal cell carcinoma and angiomyolipoma
Desmoid fibromatosis and osteomas

Question 7

Most carriers of an HFE mutation for hereditary hemochromatosis develop symptomatic iron overload.

True
False

Question 8

Which findings are part of Gardner syndrome?

Multiple osteomas, desmoid fibromatosis, epidermal or sebaceous cysts, and gastrointestinal adenomas
Multiple osteomas, renal angiomyolipomas, and pulmonary cysts
Diffuse gastrointestinal adenomas without extraintestinal lesions
Paget disease of the breast and ductal carcinoma in situ

Question 9

Budd-Chiari syndrome is caused by occlusion of the hepatic vein or the ___.

Fill in the blank

Question 10

Which vasculitis resembles granulomatosis with polyangiitis but lacks nasopharyngeal involvement and granulomas?

Microscopic polyangiitis
Eosinophilic granulomatosis with polyangiitis
Polyarteritis nodosa
Goodpasture syndrome

Question 11

Which clinical finding has the strongest association with eosinophilic granulomatosis with polyangiitis (EGPA)?

Asthma
Palpable purpura
Hemoptysis
Nasopharyngeal involvement

Question 12

What immunofluorescence pattern is seen in Goodpasture syndrome?

Linear IgG along the glomerular and alveolar basement membranes
Granular IgA in the mesangium
Pauci-immune staining
Granular C3 along the basement membrane

Question 13

Which gene mutation accounts for approximately 85% of autosomal dominant polycystic kidney disease (ADPKD)?

PKD1
PKD2
PKHD1
VHL

Question 14

Which set of findings is associated with autosomal dominant polycystic kidney disease (ADPKD)?

Berry aneurysms, mitral valve prolapse, and benign hepatic cysts
Congenital hepatic fibrosis and Potter sequence
Angiomyolipomas and pulmonary lymphangioleiomyomatosis
Wilms tumor and hemihypertrophy

Question 15

In autosomal dominant polycystic kidney disease, death is most often caused by metastatic renal cell carcinoma.

True
False

Question 16

In renal osteodystrophy, which mechanism leads to the high parathyroid hormone synthesis that causes subperiosteal bone thinning and osteitis fibrosa cystica?

Hypocalcemia from failed vitamin D hydroxylation and from phosphate binding calcium
Hypercalcemia from excessive vitamin D activation by the failing kidney
Hypophosphatemia from renal phosphate wasting
Primary parathyroid adenoma unrelated to renal function

Question 17

Which gene is mutated in autosomal recessive polycystic kidney disease (ARPKD)?

PKHD1
PKD1
PKD2
TSC2

Question 18

Which finding is characteristic of autosomal recessive polycystic kidney disease (ARPKD) at birth?

Bilateral renal cystic disease
Unilateral renal agenesis
Multiple renal cell carcinomas
Renal amyloidosis

Question 19

Small cell (oat cell) carcinoma of the lung typically arises in the _____ portion of the lung.

Fill in the blank

Question 20

Which statement best describes the differentiation and behavior of small cell (oat cell) carcinoma of the lung?

It is undifferentiated and very aggressive
It is well differentiated and indolent
It is moderately differentiated and curable by surgery
It is a benign neuroendocrine proliferation

Question 21

Surgical resection is the primary treatment for small cell (oat cell) carcinoma of the lung.

True
False

Question 22

Lambert-Eaton myasthenic syndrome occurring with small cell lung carcinoma is caused by antibodies directed against which target?

Presynaptic calcium channels
Postsynaptic acetylcholine receptors
Voltage-gated sodium channels in skeletal muscle
Acetylcholinesterase at the motor end plate

Question 23

Which genetic alterations are common in small cell (oat cell) carcinoma of the lung?

p53 and RB1 mutations with MYC amplification
EGFR mutation and ALK rearrangement
BRCA1 and BRCA2 mutations
APC and KRAS mutations

Question 24

Which complications of autosomal recessive polycystic kidney disease (ARPKD) are seen beyond the neonatal period?

Hypertension, portal hypertension, and progressive renal insufficiency
Berry aneurysms and mitral valve prolapse
Renal cell carcinoma and polycythemia
Nephrolithiasis and hypercalcemia

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